Is It Possible To........

maybe not... a lot of newer games disable it. you can prolly find a command to add to your shortcut that will allow you do get around it tho
 
Have you tried just hitting the Windows key? This seems to work with a few games, namely Counter-Strike. I always seem to hit it during a crucial gun-fight 😉 Or at least that's what I say, heh heh heh.
 
Just found out that if you have a window open on your desktop you can ALT+ENTER and it will make ya game window smaller so you can do things on ya desktop.