I'd go with the i5 7500 + RX 470 actually. Your far more "future proof" and will be able to handle more intensive games. Not to mention that the RX 470 is quite close to RX 480 performance, add an overclock, and you'll be basically at RX 480 speeds.
The G4560 is still a great chip with the RX 480. There is nothing "dangerous" about using 100% CPU usage. All that will do is create a bottleneck. Bottlenecks are not dangerous at all, just not the best to have.