FYI you can have the best of both worlds, if you want.
Install Bitdefender Anti-Virus Plus (not Internet Security or Total Security)
Install Comodo, without the antivirus component.
Set Comodo to proactive configuration.
Check that Autosandbox is on. Check that it is set to sandbox all unknown applications, and that this rule applies to all locations, not just download folder
Check that HIPS is on (safe mode, or paranoid if you like it)
Check that firewall is on (safe mode)
Check that Antivirus is not present
This last one is just my personal suggestion, since you are running BD also: you should limit Viruscope to sandboxed applications only.
There it is, now you have the top AV , plus the top HIPS, without overlaps and conflicts.
It works -- that is my setup. I am on Windows 10 x64
PS The autosandbox function, when set to all locations (not just download folder) is strong enough on its own. You don't really need the HIPS at all in this scenario.
If you like paranoia, you can run your browser virtualized by Comodo, it works great. It is like Sandboxie. You don't need to run it in the comodo virtual desktop, you can run it as a virtualized application integrated with your regular desktop.