Form over function... Only benefit to function is air path channeling, but if we wanted to get serious on that we could add customized ducting solution...
I wonder how long until we get air ducts with a screen on the top side that faces the tempered glass and aRGB strips along the edges? Moreso with a 120mm or 140mm fan mount point at the front of the duct to permit mounting to frontal fan mounts in most cases. The fan itself could even help cool the screen down should it have some vents to the screen inside the air duct path.
It'd be fancy versions of the ducted systems seen in professional PCs that are normally used to separate the CPU/peripheral chamber from the GPU chamber (which may or may not share a duct with keeping the HDDs/SSDs or newer NVMe PCIe cards cool). Heck, they can sell ATX-sized ducts that is one giant screen with ducting behind it splitting it between CPU and Cards, that fits over the entire motherboard somehow.
Is there any benefit outside of hiding unsightly cables? Does it lower the PCB layer count of the mobo or reduce the complexity in any meaningful[$] ways? If we aren't shrinking it to make it smaller or streamlining (Like 12VO), its an art project.
The main benefit I see (more for PSU makers) is shortening the PSU cables; at the very least, less wiring used depending on the case itself, and maybe even integrating 90-degree plugs at the ends or at least 90-degree plug adapters to allow for more flush wiring down the back.
Given that not many people still use Full ATX or E-ATX cases compared to the 2010s and earlier, where big cases were more common in order to shove in more SSDs, HDDs, and extra cards (audio, but maybe a TV tuner card or a second GPU), the vast majority of cases on the market are Mid Tower ATXs and smaller. Most PSU makers could take advantage of that by cutting down on the wiring and just including extension cables on high-output PSUs (say 800w and up, which are more likely to be used in larger PCs running more peripherals). Moreso since many high-end PC builders tend to run custom cabling anyway, or at least buy premade cables compatible with their PSUs.