I have a fairly new PC build but have been having this problem since the first week of use. I can only have one working USB device in a specific port. If I plug the mouse or keyboard into that USB port it will work perfectly. Any other port will cause the mouse to stop functioning after 5 minutes or the keyboard to lag at every 4 or so keys. REALLY annoying when gaming. I have tried my other keyboard/mouse from my other PC and have the same problem.
ASUS Z170-A ATX Motherboard, Intel Core i7 6700K, Windows 10 Home, Gigabyte GeForce GTX 1080 0 WINDFORCE.
ASUS Z170-A ATX Motherboard, Intel Core i7 6700K, Windows 10 Home, Gigabyte GeForce GTX 1080 0 WINDFORCE.