Mouse glitch driving me crazy

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System specs should be in my profile, but quickly I'm running an Intel 3570K at stock settings, Gigabyte Z77X-UD4H, 16GBs of I think G.skill DDR3-1600 10-10-10-30 @ 1.5v, Gigabyte 7950 WF3 with 4 screens hooked up (using 2 active mDP to DVI adapters) and an Antec 750W Green powers all this. I wasn't sure what GPU(s) I was going to buy so I went big. I'm considering buying a 400-500W Gold in the future. Disks are many. I have 7 drives running right now. 2 Samsung SSDs, a Blu Ray reader, and a number of normal hdds ranging from 250-2TB. Looking to also reduce this number by buying more larger drives.

So here is the problem. My old i5-750 on a Gigabyte P55-UD4H ran great. Even used the same RAM. Not a problem. But I didn't have any SATA 3 ports or PCIe 3.0/USB 3.0. I bought my GPU first and had issues with it. I would daily lose the monitors. Only a reboot brought it back. I figured it was some bug with the difference in PCIe between card and board. When I got the new system that problem went away, but another started. My mouse "times out". You'll hear the disconnect sound, then it will reconnect and start working again. You can hear the sound as it happens every time. I've updated USB 3.0 drivers, updated the bios, upgraded and downgraded the GPU in case it relates to that. Nothing has worked. Doesn't matter if its on a USB 2 or 3 port. Happens randomly all the time. I have tried another mouse, problem continues. Both mice are the same model so if the Logitech M100 has an issue with this board that might be it. I've tried to use a USB to PS2 adapter, but I don't have a working mouse at all. I even spent last night reinstalling windows in case it was an issue cause I did the driver trick when moving boards. Still here. If I lift the mouse off the desk/pad it will force it to happen. Otherwise it just randomly times out. Any ideas at all?

 

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And the answer is? Bad mouse. I was at walmart the other day and bought a different cheap mouse OTHER then the logitech M100. This one hasn't done anything bad in four days. Even lifting and putting it back won't cause a glitch. Gigabytes help desk tried, but they said they weren't seeing the issue I was describing. I find it hard to believe that two different (but same model) mice were broke in the same way causing the same issue. I'm tempted to say USB issue between the logitech mice and either windows or the Intel MCH. Either way I have a mouse that doesn't glitch, so I'm a happy guy.