Mouse Stop Working When Playing Games

[d00msday]

when i opened a games,my mouse will randomly play the disconnect usb chime, and stopped working,i unplugged the usb and plugged it again, it will randomly stopped working again. that happen only if i opened a games. other than play games, my mouse works perfectly fine. Just what is the problem? Thanks

 

[Ralston18]

Are you using any special game related button configurations on the mouse?

Do you have any utility software that uses some specific key combination to eject USB devices....

Open a game and see if you can match the disconnect to some keyboard key press combination.