The motherboard is just the messenger though.
If a tower cooler was used, was it removed before transport? If not, was the fan(s) removed? The latter at least makes the cooler a little lighter if the heatsink wasn't removed.
The really large towers have the potential to shift the cpu in the socket during transport, with a chance to bend some pins, though if you don't have one of these large towers, then disregard this.
Did you check for bent pins?
Was the gpu removed?
Beefy cards have the potential to warp the PCIe slot they sit in.
Did you try a different slot - if available with the motherboard?