ok, what do u guys use your PC for???

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On the Cancer note... its hard to explain in any way that will not bore the pants off most readers :/ but basically "Cure" is quite a strong word in regards to cancer. Because of the nature of the disease and the fact that its is your own misfunctional cells growing out of control and ultimately leading to your demise it is so difficult for the answer to be a complete cure... But these programs alow the comparison of vast quantities of molecular structures which may help find inhibitors, competitors and other interacting chemicals that could aid in the constant battle to beat Cancer.


Tim

ps: my PC is a home entertainment system... its my HiFi, Cinema, and Videogame arcade all in one 😱)

I can call you Betty, and Betty when you call me... You can call me Al
 
3d animation/rendering, video editing and capturing, photoshop, occasional games, video encoding, and printing images. Oh ya and seti.

<A HREF="http://www.anandtech.com/mysystemrig.html?id=9933" target="_new"> My Rig </A>
 
Composing and editing music, movie script writing, spreadsheeting, word processing and book writing, powerpointing, listening to MODule music (s3m, st3, xm, it music files), surfing web and webpage coding, email, playing Worms 2, graphic design... that about covers is :)

-

I plugged my ram into my motherboard, but unplugged it when I smelled cooked mutton.
 
exactly as stiffler said.
CURE is such a strong and final word... missleading
dozen of cancer types, all requiring differing methods of treatment.

and should we discover a potentially good molecul/drug, you cant just slap it on the market. you have to be able to make it, test it for efficacy, activity, sideeffects, toxicology etcetcetc.

what cure for cancer does is screen a large number of compounds and weed out those that MIGHT be useful anticancer agents.

besides... its better and more usefull than lookin for aliens.

Asteroid 2002 NV7: The <b>REAL</b> solution to the Israel/Palistine problem!
 
My main reason for having a PC is Software development. It's how I make my living. My 900MHZ T-Bird is plenty fast for compiling, so I see no need to upgrade it anytime soon. While I do play some games, my gForce2 MX is still fast enough for me.

My next upgrade (when I need it) will be a new machine. It just doesn't pay to upgrade an older machine (my TBird is 19 months old). Intel or AMD? Depends on price/performance at the time that I upgrade.

<font color=blue>This is a Forum, not a playground. Treat it with Respect.</font color=blue>
 
...ahem well in a way yea.

I mean it would be damn nice if there were some cases where these programs would help. If I can see an example of a good result (ok not finding E.T., but close!) I'd definitly give it a try and hell, go for 10% of my CPU if I had to!
No but seriously I guess I am too skeptical as to what these programs really give in the end, and anything to prove their usefulness, I am open to!

--
The sound of determination is the echo of will...
 
You're correct, it is nice to see progress made from time to time. The problem with publicizing every positive result that comes from any <i>in silico</i> assay like this, is that most of these targets will be shot down before even making it to animal testing. It's a very long road from finding a potential theraputic target to actually being able to use it as a therapy in people, and many things can come up in the process. The drug, peptide, etc. could be too toxic to normal cells, it might not remain stable in the system or be able to escape the immune system, the tumor cells may become resistant to the therapy, or some tumors may be affected while others keep on growing. A number of "magic bullets" have been publicized in the past just to be shot down later or to have a much reduced theraputic value. For hopeful cancer patients reading about these potential therapies in the news paper, it must be difficult to have their hopes raised then dashed. For this reason, RESPONSIBLE researchers try to be very modest about progress. You can often times read about it on the internet but you just don't hear about it in the headlines.
 
If you'd like to see that value of bioinformatics on developing cancer therapies, do a search for HKPs or Hunter Killer Peptides. Though these were not developed using Cure For Cancer, you can at least see the value of doing these kinds of massive searches.
 
Oh yes, and I use my computer for literature searches, some bioinformatics, lots of word processing, excell, and powerpoint, and some encoding and playing of MP3s... oh and (cheesy grin) porn and computer forums.
 
what is this "cure for cancer" program? never heard of it, and i`d like to learn about it. i`,m a med student, and cannot help wondering...

"Is Celeron good?"
"No. Celeron is bad."
LOL
 
hey is there any program like "gator" that would sponser biotech researches? if so,i`d like to run that, even though it might slow down the performance...

"nice to know that i`m helping the medical society."

"Is Celeron good?"
"No. Celeron is bad."
LOL
 
"If I can see an example of a good result"

So you would put your computer to use after they find a cure for cancer? The progress is process of elimination. It's sort of like brute forcing a cure.
If you have an always on connection, I dont see any reason not to help. Unless you just dont care.....

This sig runs too hot.
 
You enforced the word cure after people told me here that it shouldn't be said that way. I want examples like showing maybe that since some time of processing around the world, they might have finally narrowed down even more cells or DNA traces, at least something that shows progress as in "we're gettin' there CPUs of the world, just keep looking!".

Oh and I do care, mind you. Anybody got the website?

To TbirdXPPlus, this program along with some others like seti, allows the research labs to send information where our CPUs analyze them, thus around the world millions of CPUs are helping finding the right codes of cells, therefore helping finding cures/treatments. I find this a very genius and extremly nice idea, though the lack of any shown progress, is what is making me a bit skeptical on the effectiveness of distributed computing.

--
The sound of determination is the echo of will...
 
thx for the feedback.

and about the lack of progress...expecting a cure for cancer is probably what most people expect, but u gotta know that gleevec is probably the first anticancer agent that interfered the disease`s mechanism. previous anticancer agents were usually emperically used, it would kill cancer, but also kill the normal cells, thus resulting its side-effects.

my opinion, cancer is like infection, we know about the structure of gram(-) cocci`s, anaerobe grems, ect so we developed effective antibiotics against them, with small, if no side effects. but about tumors? frankly, not much info. has pooled yet.
the human genome project ought to kick drug development speeds up, but after translating all the DNA sequences, we got to know which part produces which protien, ect., which is a much bigger job than the rather easy HGP. as i said above, without much knowledge of the human cellular biology, drug development was much dependent on luck. now, with biology connected with computers, development will speed up. sharing your PCs computing power with these labs is like donating to the poor, might not be much, but will definately help.

if u think "cure for cancer" developmental speed is slow, u are being impatient. 100 yrs ago, we didn`t know anything about cancer(this may be misleading, case reports about tumors exsisted even then, but nothing was known about the cellular mechanism, of the tumor`s systemic effects, ect.). now, a lot of "empirical" agents exsist, (u`ve head about drugs like cisplatin, MTX?). and recently, gleevec(which blocks the Phillidilphian chromosome, the first drug that "search and destroy"s specific tumor cells. for your information, the Phil. chromosome is one of the reason for leukemia) was developed. in the future, such specific drugs like gleevec will appear for breast cancer, colon cancer, ect. u may seem that there is not much activity in the medical society, but the reseachers in the front line are having a hell of a time trying to keep up with their colleges. development is so fast, that by the time i graduate, the textbooks which the freshmens study with have already changed.

anyway, where can i get this "seti"?

thx for feedback again.

"Is Celeron good?"
"No. Celeron is bad."
LOL

P.S. sorry for my short english.
 
flaming post, eh?

nice to know, everytime i put up a post, i learn something. this yime got to know about that "Seti" program.

anyway, thanks to u all.

"Is Celeron good?"
"No. Celeron is bad."
LOL
 
tbirdXPplus.....the program is called Seti@Home......

And i really wanna know where i can get it too.....LoL

EDIT:

I found it!!! man this Seti@Home is pretty wicked......I like it.....really makes my Volcano 7 Speed up too...lol
aswell as use up my CPU Cycles that otherwise would be wasted.....really cool.....
U can download it by clicking <A HREF="http://ftp://ftp.cdrom.com/pub/setiathome/setiathome_win_3_07.exe" target="_new">Here</A>.

<A HREF="http://www.anandtech.com/mysystemrig.html?id=13597" target="_new">-MeTaL RoCkEr</A><P ID="edit"><FONT SIZE=-1><EM>Edited by MeTaLrOcKeR on 07/28/02 04:03 PM.</EM></FONT></P>
 
seti@home ive found is a great cpu stress tester. as is cure for cancer.

and im allways amused at people on these forums who boast of their super low idle temps! ROFL
my cpu doesnt know the meaning of the word idle, and ive got no idea what my idle temp is.
its either full speed or turned off. :smile:




Asteroid 2002 NV7: The <b>REAL</b> solution to the Israel/Palistine problem!
 
Lol, SETI is if you wanna find aliens!!!
I mean are you wanting to save people or find aliens dude!

BTW you got convincing arguments there. Again it is not for a cure that I need proof, just a small, a very nitpicky progress is enough. Anyway I'll give it some thought (am I being too selfish of my clock cycles?!) and I'll see.
Thanks again though...

--
The sound of determination is the echo of will...
 
Everyone knows that aliens exists, I don't see the point running seti@home - Look! Yeee we're not alone! They are only 1000 light years away.
There are more than 300 mil. computers with internet around the world, I guess. If everyone participated, there would be more news here:
<A HREF="http://members.ud.com/projects/cancer/proj_news.htm" target="_new">http://members.ud.com/projects/cancer/proj_news.htm</A>

:wink: <font color=green> The second time is always better than the first :wink: </font color=green>
 
Exactly. My little p4 1.7 is either surfing the web, playing a game, or doing cancer research (or whatever you people speculate about what the ligand project is doing). That's what i like about it, is that you can run it only as a screensaver. For a non-server computer, this is ideal (especially if the screen-saver time is set to 1 min). That way you aren't sacrificing any clock cycles you think you need, because you aren't even touching the computer. :) But it does make it hott, lol. My chip runs between 35 and 65 celsius (depending on the room temp). It's funny in the summer, because i'll accidentally leave my computer on while i'm at work and my room is about 15 degrees (F) hotter than the rest of the house :)

Athlons and Pentiums are just melted rock. Who’s rock is better? Who cares, let’s play some games
 
Refering to Cancer as a Disease is sort of strange... also people describe it as something that is infecting you and it implies the image of an invading Virus or Bacteria! Cancer is caused by the breakdown of Cell Cycle control mechanisms leading to uncontroled growth and division of them. It is your body malfunctioning, mostly increased by exposure to carcinogens, although in a few cases this is caused by a Virus and some current research is suggesting Bacterial infections. And not only by external effectors... some Cancer is caused by spontaneous mutations.

Too tbirdXPplus Combat of Bacteria as you mentioned "gram -ve cocci" (this btw puzzels me as many 'species' or types of bacterial structures, also some bacterial genomes have been sequanced - not just Gram -ve's) And briefly the reason antibiotics work so well without side-effects is because the subtle differences in the way bacteria cells functions such as penicillin that stops the creation of the bacterial cell wall by acting as an inhibitor (we as Eukaryotes do not have cell walls) But many of these Antibiotics were not originally created by us, just found naturally produced by other micro organisms ! we now modify and adapt them but the ground work was done by evolution.

The Human Genome project will help us, but many seem to look to this as the ultimate answer to everything sadly this just isn't the case... In fact it isn't a great deal of use at all other than a guide and a reference. There is so much we still do not understand about so many proteins produced by our DNA. With the massive amount of research and funding into Cancer research progress is very very slow ! and this is beacuse we need to stop ourselves destroying ourselves. It is very difficult to find the super subtle difference between a normal cell and one with a very slight difference carrying an oncogene.

Tim

I can call you Betty, and Betty when you call me... You can call me Al
 
Treatment may not necessarilly require discovering some difference between transformed and untransformed cells. In the last issue of Science Meenakshi et al., showed that, in a conditional mutant where c-MYC can be inactivated, inactivation and then reactivation of c-MYC caused tumor cells to undergo apoptosis. Totally not what you'd expect but very hopeful if most tumor cells end up being addicted to the immediate early genes activated by this transcription factor. Uh, yeah ... Suppose this belongs in a PM to Stiffler, huh. Sorry guys.

<P ID="edit"><FONT SIZE=-1><EM>Edited by cellbiogeek on 07/29/02 08:51 PM.</EM></FONT></P>
 
thx for feedback.

and, i was just trying to show an example. i understand what u r saying perfectly.

by the way, antobiotics and anticancer agents are simualr if u see it in this way.

antibiotics attack the cellular structures that are not seen in the human cell, such as cell walls, are the peptidoglycan layer.

anticancer agants attack cells in a certain phase. this is potentially dangerous; all human cells multiply, not only cancer cells. my example with glivec is this:the first drug to attack to specific "thing" in a cancer cell.

the term disease is not defined as a "microorganic infection", so refering cancer, and also allergic disorders, or even mild migraine, should all be included. this may be misleading to a lot of people, but that`s just my point of view. i define disease as a "not normal status". then cancer fits in perfectly .

the gram -ve cocci`s gengtic structure was only confirmed recently, whil penicillin was discovered much earlier than that. 2nd generation penicillins were engineered by chemisty, not genomics(at least, in the 70s).

by the way, HPV types 16, 18 are the mainon for cervix cancer...on the other hand, familial colon cancer is suspected to be caused by genetic mute(cannot remember which gene... =) ), so as many molecular biologist thinking the cancer as genetically induced, may not be wrong, but is not seeing the whole picture. (HPV causes genetic mutation, so u r right!)

again, thank you for the feedback, and i`d like to learn some more, if u are willing to correct my wrong opinions.

"Is Celeron good?"
"No. Celeron is bad."
LOL
 
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