My wife's and my kids' computers are set to go to sleep after an hour or something, but I always have mine running 24/7. The monitor is set to turn off but I run the Folding GPU client anytime I'm not playing games. I also usually leave torrents running at night since I hate surfing with them running. I've got a Q6600, HD3870, 5 HDD's (3 in RAID0), and a bunch of other crap too. I don't worry about lifespan of the components because I won't have the same hardware in 5 years. Or even 3. I pay my own electric bill (and it's clean, wind-generated) so if it costs me a lot that's my problem. I figured out once though that running just F@H costs me less than $10/month, so I'm not too worried especially if there's the possibly it can help cure somebody (maybe me, who knows). I don't fold on the other PC's because they don't have decent GPU's and it takes so long with their Athlon 64's it hardly seems worth it. If they had some decent graphics I would put them to work also.