Using regularly Opera, Chrome, and Firefox, here.
Chrome to me has the farthest to go to be the browser I want. It's limited options and capabilities are too much of a game-breaker for me, from its pathetic options menu, to features that I use all the time like mouse gestures. While I love the task manager it has, the builtin ability to resize certain text boxes, and the multi-process model, a few cool little features do not make a good browser. Worst, despite all the hype about Chrome being the most lightweight browser around, I often find that Opera (or even Firefox) uses less resources in a lot of cases for similar tasks.
Firefox lacks the cleanliness that Opera has. For good or ill, Firefox has everything one needs, but only in add-ons, which involves finding the add-ons, making sure they play nice with each other, keeping them up-to-date, taking care of compatibility issues when the add-on is incompatible with the browser version you're using, and avoiding add-on bloat. The easy drag-and-drop customizable interface from Opera would be nice to have, though. I'd also have them take tab-management pointers from Opera if I wasn't using a folder-tree style add-on called TabKit.
I'd like Opera 10 to stop bugging out and get out of beta. Easier controls to block certain flash or javascript would be nice, especially if combined with a Chrome-style task manager. Using an old (P4 2.8Ghz) computer I often see a browser (FF, Opera, occasionally Chrome) start hogging 90% of the CPU because of javascript and flash ads in the background. Chrome's ability to kill a process would be nice, but is obviously hard to implement. Tabs in Opera are pretty good, but the aforementioned Firefox add-on TabKit is a lot easier for organizing and using my tabs.