The pixel count of the higher res is what hits the hardest. In game settings would be a runner-up, as well as whether you'll bother using the RT feature or not.
A number of reviews launched today, and some concerns were answered, such as:
-Vram amount. What people see is memory allocation, not how much is actually being used. There were some complaining that 10GBs of Vram wasn't enough for the higher resolutions. Not true.
-PCIe Gen 3 VS Gen 4. Gen 4 didn't change jack - at least, not on a gpu with 10GBs of Vram; try one with 4GBs instead.