Indeed one can use three of the newest, fastest GPUs on these boards, regardless of where the PCI-E slots are located...it's important to note that when liquid cooling is used, these double-slot cards can easily be made into single-slot cards. BFG makes them that way, so that one could just buy them; personally, I made three single-slot GTX 280s by buying stock, air-cooled versions, and the liquid blocks separately. Then, I used a case nibbler tool to cut down the mounting brackets to be single slots. Pretty easy mod, actually, especially when compared to the other things that enthusiasts do, such as phase-change cooling (now THAT was a headache).