For the Dual channel configuration, both RAMs must be identical in bus speed and amount, otherwise it would be running at single channel. So 2 GB + 4 GB = single channel mode.
There's no difference between 1333 Mhz and 1600 MHz, benchmarked showed there's a slight performance increase (not noticeable) when running the RAM @ 1600 MHz.
Besides, Both Intel & AMD CPUs support maximum 1333 Mhz RAM.