Depends on what you need or what you are trying to do.
I raid 0 2x 1TB sata SSD's I use for games, the drives are going on 5 years old, It combines the drives into 1 and increases the speed in just about every category, but if one fails, I loose all the data, no big deal as I can just download the games again.
I wouldn't ever do this to files that are important to me or even if I have another single backup, I'd just keep them separated at the vary least or use a different type of raid for redundancy in an event 1 fails.
But no there really isn't much of a down fall, typically a SSD will outlast a HDD, even in server environments in a raid setting, When you raid ssd's, I don't know if this is still the case, you do loose trim, Older SSD's relied on trim command from Windows or the OS, most modern SSD's even cheap ones, the controller will do the trim regardless so I wouldn't worry to much, thats really the only downfall.
My raid 0 SSD's I first made them in Windows 8.1 (I paid too much for these SSD's at the time...), I've moved them from my old system to my new system multiple different OS installs, and im now on windows 11 and the raid 0 carried over without an issue, thats of course software type of raid like in Windows storage spaces, hardware raid would be problematic moving to different systems like that.
I did hardware raid m.2 drives on my Thridripper machine, I found it was pointless for general use and even games, m.2s were so fast anyway, like nothing really benefit from it, Video, or photo editing that has a lot of loading to do, maybe.
Good Luck!