@bnd1989
AV usage mostly resumes at button clicking, if at all. By "manually cleaning" you mean hijackthis & co.? The single "manual" interaction still resumes to clicking "fix checked" or not, just that you have a somewhat larger pool of targets to choose from (and could eventually ask someone more knowledgeable on forums for help, and not deleting useful stuff).
Don't tell me you're browsing the registry (one of the biggest me$$es created by m$), or the filesystem (also not much lees me$$y), to find dubious entries/files (for more of 99% of these, you don't have the slightest clue, what they're for).
Almost exclusively, "protection" offered today for windblow$ is just some internal, or 3rd party app, which scans for known fingerprints/symptoms.
If you need real protection (never 100%), then you must use an OS with a secure layered architecture (m$'s schweitzer cheese doesn't apply), and sane usage habits.
I really don't feel any smarter at all, by using these techniques to clean the mess on some windumbed system, at most I've gathered more experience.
Due to m$'s style of undocumented system calls usage (it's nice - for microsuxx - to have some hidden aces up the sleeve), it's quite difficult to follow what (knowledgeable) virus writers are doing - also this is getting into a very specialized field, for which I have no attraction (have better things to do than clean m$'s me$$).
It doesn't make me "proud", whatever the "other Stevie" is saying about his lusers (I'm not one), but most macs are bought by people with above average sized pockets, with in itself correlates well with higher IQ (with the notable exception of retarded kids of rich parents). As a sidenote: high IQ is not obligatory associated with high IT skills.
Regarding OS comparing, you're still coming up with niche applications: conversions, gaming... You can't make a true comparison, without taking into account all possible applications to use, and even then it mostly depends on the app itself, than on the OS. It's much easier (and fair) to compare OSs (in combination with the desired apps) for a (few) specific purpose(s) you're interested in, to make your decision. There is no "fits all" solution, as m$ & fankiddies are trying to impose on everyone.