I think the airflow will be fine. I would say its probably about equivalent to an open air test bench. I can't see there being a problem with airflow. The dust is a different story, because it is open to the air, it is going to be easier for dust to accumulate on the gpu and cpu coolers. It all depends on your environment. If you have pets, it could cause it to accumulate faster. I mean it shouldn't be an issue at all as long as you clean it out once a year or so. Thats what I do with mine and I don't have any pets.