Cyberpower PC with that configuration looks fantastic, has components that are great and it's priced right. That makes it stand out above the rest. Plus, it's a hassle-free closed loop for both the CPU and GPU? Yes please!
Digital Storm makes beastly builds, it's tough not to want something that sexy and who wouldn't want four-way SLI with Titan Blacks? It's over the top, though you'd expect two 4 TB HDDs in RAID 1, if you're going all out.
The FragBox from Falcon Northwest also stands out because of the form factor, though it's still steep. Two Titan blacks and all the other goodness packed in a case that's mobile begs for a 4K projector and a LAN party, provided that HDMI 2.0 for full 4K at 60 FPS is feasible.