You want positive airflow in the case. That means more air going into the case then exiting. If you fill the case with air it'll push air out of the cracks and keep dust out. If you put all fans as exhaust or pushing out it hauls air through the cracks and dust along with it. Remember that the PSU and Video cards exhaust air outside the case, so you need enough fans bring air into the case to counter the PSU and video card, and some more to create that positive air pressure.
If you have dust filters keep those clean.
I'm not a fan of air cleaners. They blow dust into areas they shouldn't go such as hard drives, cd roms, fans, etc... If you use air you should remove your components, bring them outside, and blow them clean. I prefer a micro electronics vacuum cleaner. There is no need to disassemble the PC and it removes all the dust instead of just blowing it around.
A UPS is never a bad idea. It'll eliminate all power surges and if you have a brown out for a second your computer will stay on instead of shutting down midway through a process like saving a file.
Other than this no maintenance is required. The only problem you will get is the odd virus or spyware if you're a total noob and just don't have a clue what you're doing and click everywhere. Some people will search the web and click on any link not having a clue what they are doing and get spyware galore.
ie. You want to go to ford's website and look at their cars. I would type in ford.com and go directly there. Some people open chrome (or what they call google or some even call it the internet) and search for ford. The first listing could say ford of america, check out our cars. They click on it and bamo full of spyware. They didn't look at the link below the listing that had a description for ford, but the link was actually
www.spyware.com/you are a sucker.com. Some butthole made a website for spyware with a description of ford cards to sucker people in.
Or you can tell people to go to the website
www.ford.com and they will search for
www.ford.com instead of typing it in the address bar and going directly to the site. Just plain not knowing how to browse the web efficiently. And you can tell people this stuff all you want and they never learn. It's bad habits like this that give you tons of spyware while people who know how to browse the web never have a problem.
As soon as people bring me an HP, Dell, Acer, etc.... to fix I know the problem. #1 since they bought that computer in the first place they probably don't know what they are doing so they don't have a clue how to browse the internet, and they are full of spyware. 29 times out of 30 this is the case.
Moral of the story. Don't worry about maintenance. Clean the major dust from the case fans and heatsink on the CPU. Don't get too crazy like some people with cans of air outside. A UPS is a great investment to prevent a possible power problem that probably never would happen but if it does you just saved your system. And learn to browse the internet properly to avoid getting malware/spyware in the first place.