I have found that case ventilation needs vary greatly with the hardware, obviously. Vidocards seem the be the dominant variable, where the more heat the GPUs give off inside the case, the more beneficial side mount exhausts are. It is always essential the have good evacuation of warm air from the CPU HSF, whether from the back or top. Front mount intakes always make things better, heh.
Before I installed my 4870x2, I didn't use a side mount fan, just 120mm fans in the front and back, with a loose funnel vent to the CPU HSF and an open grate over the PCI slots. The x2 produced enough heat to warm my CPU dangerously during gaming. I added a 120mm side exhaust to the grate and the problem dissappeared.
When I upgraded the stock CPU cooler, I rigged a direct airflow tunnel to my CPU HSF (top mount fan). This is also around the time I replaced my 4870x2 with my original 4870 512mb. I left the side exhaust on, and noticed a very healthy drop in my GPU temps compared to before I had it. This 4870 now idles at 44c, before would idle at 55c. I have yet to see it break 80c during gaming now, and before it would often breach 90c.
There is no solid formula for ventilation, each build/environment is different, but it never seems to hurt to go for more. 😀