I think a heat sink/blower combo would be very interesting. Blowers do not have the "blind spot" that fans have. I remember that Cooler Master's JET4 cpu cooler was a good cooler in its days, but suffered from high noise levels. I would like to see a heat sink (tower type, with heat pipes, it doesn't necessarily have to be a top-down configuration) with a blower mounted on it. The intake of a blower should have a bevel that you can use to attach a tube/duct so it can draw cool air directly from outside the case. The exhaust air could be directed towards the back of the case. I think that mounting the blower so it sends the air stream upwards, towards the top of the case (where you have the PSU of another fan) would not be possible because it would most likely collide with the northbidrge heatsink and/or the VGA card.
The whole idea is to improve the uniformity of airflow through the fins of the heat sink while also providing a separate airflow path for the CPU cooler.
Here's a drawing:
www.mapa.go.ro/heatsink_blower.bmp
In my point of view, blowers could also be used to create single slot GPU coolers, with a blower type (tube shaped blower) fan at the end of the VGA card.
Also, a long, slim blower (1 cm diameter) would be nice to have. I would use it to push cool air underneath the motherboard. Also a case that would have a long, rectangular mesh to provide and exit point for the air underneath the mobo would be nice. A lot of manufacturers use the bottom layer to create big copper areas that act like heat sinks. Providing airflow to this side could lead to better VRM termperatures, thus improved stability and life time.
Another ideea: direct touch coolers. I would try to get rid of the aluminum fins between the individual heat pipes. I would try to create heat pipes that have a rectangular cross section in the area where they have to form the heat sink base. The heat pipes could be soldered together using a process similar to re-flow soldering. A U shaped piece of aluminum could be used to wrap the sides and the top side of the heat pipes to provide strength and a suitable point for attaching the retention mechanism. Using rectangular shaped heat pipes would allow to create an improved active surface. Also, if it would be possible to engineer the heat pipes so the side that is in contact with the CPU is twice as thick as the other walls. This would allow better finishing of the heat sink base.
Here's what I mean:
http://www.mapa.go.ro/rectangular_heatpipe.bmp
Water cooling: It would be interesting to add peltier elements in the water tank for example. They would be used to lower the temperature of the water below the room temperature. Of course, the peltiers have horrid efficiency and generate a lot of heat on the hot side, but the purpose is to limit the temperature of the cooling fluid to a point above the temperature that could create condensation on the tubes and metal parts (water block for CPU, GPU, etc).
I would also like to see some kind of distribution system: a thick tube, ~20cm long with output ports for coolant distribution for every water block. A similar part would be used to collect the incoming war coolant. Also increasing the water quantity helps because of the natural thermal inertia of water.
To sum it up: i think blower could offer some interesting design possibilities. I like the most the fact that they produce a 90 degrees "bend" in the air flow. They could be used for CPU, GPU and backside of mobos coolers.