Yeah, it is a really good motherboard. The FSB supports Core 2 Duo which is a major part, but there are some voltage changes that might be needed. I looked in the BIOS updates, they mention something about CPU microcode or something. I'd ask with Gigabyte to make sure.. If you can get a Core 2 Duo, that thing will be blazing!
Yeah, 4 7950GX2's might need another mortage, lol...
~Ibrahim~