Asus R6E and 2 small questions

Feb 5, 2019
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Hi, i am building a new pc and since it has been over 14 years from the last i built i am a bit rusty.

I bought below parts and i am starting to put them together
1- Asus Rampage VI Extreme
2- Dual Asus Strix 1080TI OC in SLI
3- Samsung 1TB NVMe
4- Delidded I9 7940x
5- 32GB DDR4 3200MHZ Ram

What i want to ask is;
1- I know that R6E is a high end motherboard and have premium quality onboard sound but i am considering buying 2 or 4 studio monitors (dynaudio lyd 7 to be exact) and a sub to have 2.1 or 4.1 sound environment, can onboard sound handle those monitors or should i buy a dedicated sound card like "STRIX RAID DLX" or "Xonar Essence STX II" ? Would there be a noticable difference between onboard and dedicated sound card, would i benefit from a dedicated sound card? If i do, which of those cards above should i buy... I know that audio is a subjective topic but since i never bought studio monitors i want to make sure i get it right and have the best sound i can...

2- Considering i will be using 2x1080TI in SLI and possibly a sound card, where should i put my NVMe drive? Should i put it to m2 slot under the cover which uses PCH or to the slot right next to rams which uses CPU?