I made a series of horrible decisions back when I was 15 and building my first computer, sometime around 2003ish. I made the decision that I was going to try water-cooling. I had purchased one of the top of the line AMD CPUs and a overclocking friendly motherboard and a water-cooling kit. Not the AIO popular kind you see today, those didn't exist. This had a pump/controller that sat in the 5.25" bay. I get everything assembled properly and decide to give it a test run. I turn her on and was greeted with the lovely smell of burning electronics.
After disassembling the PC and reading the manual for the water cooler I realized I had missed one extremely important part in bold on one of the pages. "DO NOT POWER ON THE PC WITH THE CPU INSALLED UNTIL COOLING LIQUID HAS BEEN FULLY CYCLED THROUGH THE PUMP". So it turns out I never actually installed the cooling liquid into the system and immediately fried the CPU.
I chalked it up to a beginners mistake and bought another CPU. Installed it into the motherboard with every installed properly including the liquid cooling. It wouldn't boot. It would turn on but it wouldn't give me any video. I thought, okay, maybe I damaged the motherboard and bought a new motherboard. Installed it with the previously newly bought CPU, same thing. Boots with no video.
Finally giving it up I took it to a professional PC repair place which told me that I had fried the CPU and motherboard the first time. When I replaced the CPU, the fried motherboard toasted the new CPU. So when I bought the replacement motherboard, installing the newer fried CPU also fried the motherboard.
All together I had killed two motherboard and two processors. Eventually I bought both a new CPU and motherboard and got it running, but that was an extremely costly series of mistakes...