Ah, but wait... there's more!
Let's consider some of the additional variables involved in the memory big picture:
A ratio of 1:1 provides the best level of stability, since the memory controller, which is an integral part of the northbridge chipset for Intel Core 2 processors, does not need to translate data flow across the FSB between the memory modules and the processor(s). Also, since memory and processor FSB clocks are synchronous at 1:1, (400:400 or DDR 800), there is no additional latency introduced.
If a minimal ratio of 4:5 (400:500 or DDR 1000) is used, then the resulting increase in memory frequency is effectivey cancelled out by the latency introduced in translation across the FSB between memory and processor clocks, and no increase in memory performance can be noticably detected in benchmarks. Also, asynchronous or mismatched clocks create an element of potential instability within the memory controller, so depending on the chipset, an increase in northbridge and memory voltage is required for stability, which results in more heat, and less FSB overclock ceiling.
If a more aggressive ratio of 2:3 (400:600 or DDR 1200) is used, then the increase in memory frequency can marginally overcome the latency introduced in translation across the FSB between memory and processor clocks, resulting in a marginal increase in memory performance, which typically yields an increase in memory benchmarks of 2 to 3%, and is relatively negligible in terms of overall system performance.
In the case of DDR3, where a ratio of 1:2 (400:800 or DDR 1600) or 2:5 (400:1000 or DDR 2000) is used, even with the tightest timings, an increase in memory benchmarks of only 3 to 4% is yielded over DDR2 800, which once again, is relatively negligible in terms of overall system performance. It's also noteworthy to consider that DDR2 memory timings of 4-4-4-12 compared to 5-5-5-15, will yield an increase in memory benchmarks of less than 2%. However, for those of us who have the need for speed, we'll take whatever we can tweak.
Additionally, at equal specifications, 4 memory modules offer less FSB overclock ceiling than 2 modules, since more northbridge and memory voltage is required to maintain stability, and 4 slots require twice the current of 2 slots, again resulting in more heat, which typically is pulled into the CPU cooler, where it can increase processor temperatures by a few unwanted degrees.
I hope this helps to provides a greater degree of perspective (no pun intended).
Comp