What CPU?
It matters since the securing method of CPU vastly influences the methods where you can achieve what you want.
For example, if the CPU is secured with a ZIF PGA like many amd, it is very easy to do so since the cpu is secured by the pins. (still will have to deal with the mounting to lay lower on the die without IHS)
For the LGA type the IHS has some tabs where the clamp presses on to and you need some risers (the exact height as the original IHS) on the CPU package in order to properly secure the cpu in the socket and then still you have the issue that the die is recessed in the mounting so the heatsink must be milled to have a pround surface just for the die to not interfere with the surrounding socket. The best adaptation for either intel or Threadripper that use LGA is the IHS itself milled in center to remain with the exposed die in center and retain the original bezel that is needed for proper mounting.
On LTT it was presented a direct die watercooling block.
View: https://www.youtube.com/watch?v=n4O_Dq3xRJA
And Der Baure makes some brackets for direct die cooling
View: https://www.youtube.com/watch?v=DJOVdmd7NHQ