It'll run but you wont ge able to use SLI to link the cards. For gaming the 2nd card could be used for physx in the few games that support it. DX12s multi gpu mode is along ways out from widespread usage (currently 1 game supports it), so for gaming the 2nd card is almost useless. There are rendering and mining programs that could utilize it with SLI. So it depends on what you are wanting to do with them