I have ccleaner run a custom cleanup at start-up. I'm going to assume that helps any AV scan right off the bat. Webroot's AV has the option you can select or deselect "Only New Files or Files That Have Changed" when doing a manual scan.
I really appreciated my system even more over the weekend. I was helping a friend by removing virus/spyware from his dated laptop. It was running on a celeron 1.3-1.6ghz (cant remember exactly), 512MB ram, 30 something GB IDE HDD, with Windows XP. OMG! If the author had tested the different AVs on this system, he'd still be running the tests. I put it thru the normal paces, like downloading/installing/scanning with Ad-Aware, Spybot, ccleaner, webroot spysweeper, etc and then go in manually checking msconfig/services.msc/regedit. I manually examine every .exe on the root, windows, and system32 directories. Uninstall all that software, throw on MSE, one final scan, and call it a day... not. I didn't stay on top of it all day, every day, but I didn't feel comfortable with calling it finished until the 3rd day. Finalized the removals, added over 100 security updates and service pack 3, as well as a copy of openoffice.
The main point from all that rambling, is that on that system, everything took forever to complete.
I'd like to see this round-up done again with more products. I'd like to see it on something more mainstream like a core 2 quad 6600 with 2-4GB RAM, and any decent 7200 rpm HDD. I think that would be sufficient to produce noticeable differences in performance between the various products.