When I first got on the net, back in '99 I think, I was using an HP desktop (my first and last pre-assembled desktop) which came with McAfee. My wife lost about 80GB of photos to a virus. Since then I'd settled on AVG free, Lavasoft Ad-aware, and Spybot S&D to stop or find the nasties, and ccleaner to clean up after them. Then last year I was playing a FPS when the game got shut down to ask if I wanted to install an update from Ad-aware. Game over for Ad-aware.
And then over the last six months my web browsing started getting really slow. I've got a 2MB/s ADSL2 connection, and I can play MW2 online just fine, but my browsing was down to dial-up speeds. I uninstalled AVG and the speed came right back up. So, where to go for AV? I tried MSE which didn't seem to slow anything down, but it kept telling I might be unprotected and I needed to do a scan, usually just after a scan had finished.
So I tried the Vipre trial about 2 months ago. So far it seems fine, and I did actually get the family licence, which is a first for me. Its early days yet, of course, but so far it has kept nicely in the background and not bugged me.