I was lucky enough to have one in my case (without side vent), it runs fine at 1100/1500. Initially I was really concerned about the fan speed and the high pitch noise it will generate, before I bought it. But in my under the desk set up, it runs pleasantly quite, even when gaming (COD BO2 2560x1600 max details). Admittedly, my case has 5mm aluminium panels (Zalman Fatality case), which may reduce the high pitch noise.
My major issue was with the length of the card at 295mm, which was quite a bit longer than my replaced 8800GTX . This card was just 5mm too long to fit properly, without unmount and move the HDD cradle a little. The thin cabling at the end of the card, needed to be pushed it to avoid damage during installation.
Comparing to the 8800GTX, it runs so much cooler, and performance gain was phenomenal. Although I don't do any GPGPU compute on the card, I'm pleased to know the potential is there, should I ever need it.
I believe this cooler design is great for running Crossfire. Cooling was one of the biggest issue with my 8800GTX's. I can see the new design will allow two card to run without worrying too much about the top card going in to heat stroke (this is the reason why one of my 8800GTX died). But I guess this wouldn't matter so much now, when it is difficult to get hands on 2 of this cards ;P Sacrafice two PCIe slots is a big draw back.
Overall I give it a thumbs up for its unique cooling design and good performance/price ratio.