I'd have no problems dropping a Supermicro/Tyan server board in there and filling the thing up with as many SAS hard drives as I could get my hands on, though I'm past the days of making my desktops as big as they can possibly be - a lower-high-end mATX/ITX system is more than enough if done properly.
I bet this thing isn't going to come cheaply, and tack shipping ontop of that MSRP, too. Interesting case, though... I could see myself buying one if I ever come up with the budget to get that Xeon workstation pulled together for 3D rendering projects.
You might not want to make your case larger than it needs ot be, but those of us with large NASes (19 drive raidZ3 in mine...) would welcome something like this, even if married to a ridiculously small mainboard (the octocore embedded atoms are more than sufficient for the NAS part).
A NAS for home has asthetic requirements(*) you don't need to worry about in a server room (BTW, the cases I do use in server rooms hold 60 drives, which slide out on rails for easy access - but they're noisy)
(*)1: No fugly front panels, unless you want to end up sleeping in the case. 2: Decent dust filtration 3: QUIET!
All of the home cases I've seen - including the D8000 and caselabs/mountainmonds come up lacking in one or several of these areas without extensive modification.