Microsoft, like any other company, is "all about money", they ARE a business after all. I don't think that we'll see too much happen overnight to Skype. What we will see is Skype patents and IP used in Bing, XBOX, Microsoft's hardware division, Windows and Windows Live and particularly Office. I think that Microsoft can make the Skype network greater with their resources and reach, and even get it in the hands of professionals through their powerful Server and Enterprise division.
Chances are you use a product or service that is owned by Company XYZ and you don't even know it. I think of this as a good thing for the web, for multi-platform Skype users and for Microsoft (which many people still use IE, etc.- and would benefit from this acquisition.)