Question Motherboard (ASUS Tuf x570-PRO) RGB lit but no response to power button or jump

[AsAnthracinus]

Recently bought an AIO cooler cause things were running pretty hot. When I chose to install it, I removed the motherboard from the case and blew everything out with compressed air (because why not clean things up while you've got it apart, right?)

After some shuffling of fans around the case, I had the thing installed and ready to go. Plugged it in, flipped the PSU switch and the motherboard's RGB lights came on. But when I pressed the power button, I got nothing.

Things I've tried:
Jumping the pins of the power switch with a screwdriver
Pulling and replacing ram sticks.
Pulling and replacing the BIOS battery
Pulling the whole motherboard out, disconnecting everything, and connecting it to a backup PSU
(again, tried everything above with the new PSU)

I'm stumped! Anyone got any ideas?

 

[Aeacus]

With all that tried, only thing left is MoBo replacement.

As of why your MoBo died, well... ESD is one likely option.

 

[AsAnthracinus]

With all that tried, only thing left is MoBo replacement.

As of why your MoBo died, well... ESD is one likely option.

Thanks for the reply...guess I was kind of expecting that. I'm not terribly tech savvy so if you wouldn't mind...what's ESD?