What are you looking to replace, just the motherboard? Are you planning to reuse the CPU and the DDR2 memory?
What you also need to consider is if the I/O Backplate on the chassis is replaceable. If it's not replaceable you will have to find the exact same motherboard or you will have to do some sheet-metal work modifications to your chassis so that you can use the I/O backplate that is included with the new motherboard.
Do you still require COM or LPT or PATA connectors?