To verify that I understand the problem:
Two known working mice (known to work via other computers) have the same problem on your PC - correct?
Specs noted but more information is needed:
PSU: make, model, wattage, age, condition (original to build, new, refurbished, used)?
Disk drive(s): make, model, capacity, how full?
Look in Task Manager and Resource Monitor for any unknown or unexpected apps/processes that may be running.
Use both tools but only one tool at a time. Leave tool window open and viewable. Work or game etc. as usual.
Watch the tool window for what changes when the mouse behavior changes.
May take a bit of trial and effort to work out the observation method. Take your time.
Also: have you run any anti-virus/malware scans?