You can run the ram any way you want but it depends what you want to achieve. High bandwidth,best speed or a combination. Running 1:1 with tight timings is as good if not better than running on a higher ratio with looser timings although with a lower bandwidth.
So a q6600 (450x8) with memory DDR900 on 4,4,4,12 is equal in response to running memory 1125 5,5,5,15 but loses a bit of bandwidth. Depends what you want - trade bandwidth for speed!. Good overclocking 6400 memory has a good chance of running tight timings upto 1066 but good 8500 with D9 chips has better chips and is more likely to run the tight timings below rated speed at these frequencies so potentially gives the best of both.
Have a look at this detailed arcticle and download the overclocking speadsheet and compare figures u want to try out. - the author knows what he is talking about. http://www.thetechrepository.com/showthread.php?t=195