Question Random game crash, mouse stutter and slow response ?

[Aeacus]

I unplugged HDMI from Video card and re-plugged and haven't had an issue in a few hours

It is sounding more and more that you have an issue with your GPU. And it may not be drivers/software issue, but instead hardware issue.

Software wise, formatting your OS drive and making a new, clean Win installation, will get rid of all software issues, including bloatware and malware (except rootkits). So, software wise, Win clean installation is last ditch effort to fix things.

Now, if issue is hardware, there is one more thing you can do, to narrow things down;
remove your GPU from the system completely and connect monitor to MoBo. This way, you'd be using iGPU inside the CPU.

If everything is butter smooth when using iGPU and there are no issues, your RTX 2080 Ti is the problem.
In this case, only fix is new GPU.