Having not played any of the Fallout games, my approach will necessarily be pragmatic. How much time has passed? I'm 55 now; is it next year, or ten years from now, or longer? If longer, why have I not croaked already? Am I alone, with strangers, or did I get to safety with other members of the prepper group I'm in now? If the latter, we're good; we've got tools, seeds, basic skills, and collections of manuals on eReaders and other non-volatile storage, and enough solar stuff to keep these things (and our radios) charged, while we scout an area and build. Is the world teeming with natural life, or essentially barren everywhere? Any civilization out there, or just animals (some on two legs)? Reconnaissance would be a Big Deal, as we make our way to a likely place to make a fresh start. What we find governs what we do.