Here is MY experience updating to an RX 480!
System: Core i5-6600K, at 4.0 GHZ, 16 GB DDR4-2800 MHz RAM, 254 GB SamSung 850 PRO SSD, 1.5TB Western Digital HD, Viewsonic 1920x1080 144Hz monitor with Freesync. Win 10 64-bit.
My old graphics card was a Sapphire Dual-X R7 265, the new one is the Sapphire Nitro RX 480 4 GB. I ran the benchmarks with the old drive, installed the new drive with the same settings, and ran them again.
Furmark Score: 1832 to 4004
Furmark FPS: 30 to 66
Resident Evil 6 benchmark: 6787 to 15287
Dragon Age:Inquisition Benchmark: Min 35 Avg 41 to Min 77 Avg 90
Tomb Raider (the 2013 one): 28 Min 50 Max 37 Avg to 74 Min 118 Max 96 Avg
Bioshock Infinite 27 Min 50 Avg to 60 Min 168 Average (!)
Fallout 4 (average of 3 runs from a certain save for 1 minute in FRAPS): 35 Average to 76 Average
Witcher 3 (average of 3 runs from a certain save for 1 minute in FRAPS): 33 Average to 53 Average (80 to 85 FPS on High+settings now, I had hairworks on for some stupid reason).