It is usually impossible to do this on most motherboards. The "USB Bus" entails all ports, so if you were to disable the driver it would disable all.
If you really wanted to, you could physically disconnect the headers inside the case of the machine.
Or you can buy "USB protective covers".
On the off chance that your machine does allow it though, navigate to the Device Manager, expand the USB controller, and see if you can see each port. If so then you can simply Right Click + disable.