I hardly think that with Apple's recent surge in popularity amongst teenage girls, hipsters, and angsty slam poets, losing some loyal graphic designers/media enthusiasts will spell disaster for the company.
I do think that Apple's ego is a *tad* overinflated at present, though, and wouldn't mind seeing someone reintroduce them to the concept of humility.
E: This in response to those speculating that Adobe could/would/should abandon Apple altogether over Jobs' criticism of Flash. I don't see that happening, realistically. Just speculating that it wouldn't be the end of Apple's world if it did.