I wouldn't. It might drop, and might reconnect also, multiple times in quick succession. I'd be concerned about data loss on any drives. Power down, then remove and reseat all connectors.
I discovered I had only put 4GB of RAM in my wife's PC. So, a RAM shuffle ensued; a 2x8GB kit went from the shelf to Omega, Omega's 2x4GB kit went into Greenhouse (my wife's PC), and her 2x2GB kit went to the shelf. All are running fine (except the shelf; it hasn't so much as twitched).