Question Wondering why my computer won't boot with 2 ram sticks

[Quasxen]

System specs:
New MSI MPG x570 Gaming Plus motherboard
New AMD Ryzen 7 3700x
New G.Skill Trident Z RGB (2x16Gb) ram

If I install 1 stick the system will boot up. If I install the second stick, the motherboard diagnostic led says there's an issue with the CPU or it'll say there's an issue with the VRAM/CPU.
I get the same results if I use 2 of my old RAM sticks I was using in my older x470 Gigabyte motherboard (I was running 4x8Gb on that one).

At this point I don't know if the issue lies in the CPU, RAM, or motherboard. Though using a single RAM stick the system seems to run perfectly fine

 

[Quasxen]

Further testing may suggest a double issue.

Single stick in A1 slot - system will boot but lets me know it's not the optimized slot
Single stick in A2 slot - system boots and functions normally
Single stick in B1 - dead with CPU motherboard LED on
Single stick in B2 - dead with CPU motherboard LED on

Other RAM stick in A1 - dead with CPU/DRAM motherboard LED on
Other RAM stick in A2 - dead with CPU/DRAM motherboard LED on
Other RAM stick in B1 - dead with CPU motherboard LED on
Other RAM stick in B2 - dead with CPU motherboard LED on

Would it be safe to assume that while both sticks were slotted the motherboard B channels fried out and took the RAM stick with it?