That chassis is unique. It's marketed for negative pressure(exhaust is stronger than intake) and is preinstalled with a rear and top exhaust fan.
The stock config has been shown to be the best overall - as far as air cooling is concerned, anyways.
Link #1.
Link #2.
I would save the front panel for a 240/280mm AIO to cool the cpu or gpu, depending on which is the hotter component.
All that said, the chassis does have it's downsides, the primary one being the kind of hardware it can accommodate.
It struggles with both a high power consuming cpu and gpu - for example, a 9900K + 2080Ti.
You'd only be able to cool one - the 2080Ti, in this situation - so that leaves the 9900K to be cooled on air, which technically, should be fine, but you can forget about overclocking it.
NZXT did answer this shortcoming with their H700 series.
I don't think you'll be able to avoid using liquid cooling in any of those cases if your hardware consists of a 9900K-like cpu and a 2080 Super or higher power consuming gpu.